SCREENING USING RELEVANT BIOMIMETIC MATERIALS

by Alvin Kuriakose Thomas, Nadine Schmieder-Galfe, Yixin Zhang

The matrisome is an inventory of extracellular matrix proteins. The core matrisome comprises of about 300 proteins in mammals, in addition to matrix modifying enzymes, growth factors, and other associated proteins. Interactions of the various proteins in the extracellular environment provides the physical and chemical stimuli for biological responses. The modular, yet diverse nature of the extracellular biomolecules reflects their role in evolution, templating the transition to multicellularity and further on.1 continue reading… “SCREENING USING RELEVANT BIOMIMETIC MATERIALS”


THERAPEUTIC GRADE BIOMIMETIC MATERIALS

by Alvin Kuriakose Thomas, Nadine Schmieder-Galfe, Yixin Zhang

Synthetic materials have become an integral part of healthcare devices such as implants, prosthetics, wearables etc. The development of synthetic biocompatible materials for tissue engineering using stem cells holds promising therapeutic opportunities.1,2 Pluripotent stem cells require a niche environment to maintain their ability to self-renew and differentiate.3 The in-vitro sustenance of several stem cell types has been well established on the extracted extracellular material, commonly known as Matrigel®, a gelatinous protein mixture secreted by cancerous mouse cells.4 In practice, extracted extracellular matrices are utilized to mimic the extracellular environment for generalized research purposes.5 However, the benefit of transplanting these stem cells cultured on the extracted material into patients, is limited due to the risks associated to its animal origins, immunogenic proteins and unknown pathogens. Another major concern of use such extracted biomaterials is the lack of medical grade quality, since the complex mixture of biomolecules is neither defined nor reproducible.6,7 continue reading… “THERAPEUTIC GRADE BIOMIMETIC MATERIALS”